Pediatric venipuncture is often challenging due to small veins, limited cooperation, and high anxiety among infants and young children. A clinical study from Puning People's Hospital in China evaluated the effectiveness of vein visualization technology in 500 pediatric patients and demonstrated its potential to improve first-attempt success and nursing efficiency.

Venous access can be particularly challenging in oncology patients because repeated venipuncture, long-term treatment, vascular fragility, edema, and other clinical factors may make veins difficult to identify. A 2025 prospective clinical study at Anyang Cancer Hospital investigated the use of optimized lighting combined with a vein visualization device during venipuncture in 240 patients. The reported results showed that the combined approach could improve first-attempt puncture success, with the highest reported success rate reaching 98.3%, while also reducing puncture time and pain scores. These findings highlight the potential value of vein visualization technology as an auxiliary tool for improving venipuncture efficiency and patient experience in oncology care.